Dr. Gange attended Tulane University where he earned a Bachelor of Science degree with Honors in Chemistry. A Ph.D. in chemistry was awarded to Dr. Gange by The Ohio State University for studies in organic synthesis. After two years of post-doctoral studies in organic synthesis at Columbia University, Dr. Gange accepted a position with the American Cyanamid Company. In 1996 Dr. Gange joined Transcell Technologies, a pharmaceutical start-up, as Assistant Director of Chemistry. In 2001 Dr. Gange joined Row2 Technologies as Vice President of Cheminformatics Solutions. In 2003, after a successful stint with Row2 Technologies, Dr. Gange founded Altimatia, L.L.C.
Dr. Gange is a member of the following organizations:
U.S. Patent Application Number 10/448,168: System, Apparatus, and Method for User Tunable and Selectable Searching of a Database Using a Weighted Quantized Feature Vector.
U.S. Patent 5,599,832: Indoles as Insecticides and Acaricides.
European Patent 697,172: Preparation of Indole Derivatives as Insecticides and Acaricides.
U.S. Patent 5,502,071: Indoles as Insecticides and Acaricides.
AU 4,322,799: Carbohydrate-Based Scaffold Compounds, Combinatorial Libraries and Methods for their Construction.
U.S. Patent 5,391,757 Benzenesulfonyl carboxamide compounds, intermediate compounds and methods of preparation thereof and use of said compounds and intermediate compounds as herbicidal agents.
U.S. Patent 5,338,883: Benzenesulfonyl carboxamide compounds, intermediate compounds and method of preparation thereof and use of said compounds and intermediate compounds as herbicidal agents.
U.S. Patent 5,252,539: Benzenesulfonyl carboxamide compounds, intermediate compounds and method of preparation thereof and use of said compounds and intermediate compounds as herbicidal agents.
BR 8,804,127: Benzenesulfonyl carboxamide compounds, intermediate compounds and methods of preparation thereof and use of said compounds and intermediate compounds as herbicidal agents.
U.S. Patent 5,180,419: Herbicidal 2-(2-Imidazolin-2-yl)-benzo-(5-membered)-heterocycles and use therof.
U.S. Patent 5,120,854: Benzenesulfonyl carboxamide compounds and intermediate compounds.
U.S. Patent 4,992,094: Phenylsulfonyl 2-imidazolin-5-one compounds.
U.S. Patent 4,883,914: Benzenesulfonyl carboxamide compounds useful as herbicidal agents.
The Use of Electronic Reaction Databases in Process Chemistry. Curr Opin Drug Discovery Dev (2003) 6, 362.
3-Azido-3-deoxy-glycopyranoside Derivatives as Scaffolds for the Synthesis of Carbohydrate-Based Universal Pharmacophore Mapping Libraries. Bioorangic and Med Chem Lett., (2003), 13, 2185.
Antibacterial Activity of Synthetic Analogues based upon the Disaccharide Structure of Moenomycin, an inhibitor of bacterial transglycosylase. Microbiology (2000) 146, 3129
Calicheamicin-DNA Recognition: An Analysis of Seven different Drug-DNA Complexes. J. Am. Chem. Soc., (2000), 122, 8403.
Inhibition of Transglycosylation Involved in Bacterial Peptidoglycan Synthesis. Current Medicinal Chemistry,(2000), 7, 801.
Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library Approach. J. Med. Chem., 42, 3193, (1999).
Herbicidal aryl thioalkyl phosphonates. Proceedings - NOBCChe., (1997) 24, 185.
Carbohydrate-Based Small-Molecule Scaffolds for the Construction of Universal Pharmacophore Mapping Libraries. J. Org. Chem., 63, 2802, (1998).
Beyond CHELP: Improved Potential Derived Charges for Sugars. Glycoconj. J., 14, 501, (1997).
The QSAR of Insecticidal Uncouplers. ACS Symp. Ser. 606, Classical and Three-Dimensional QSAR in Agrochemistry, 199, (1995).
Charges Fit to Electrostatic Potentials: Can Atomic Charges be Unambiguously Fit to Electrostatic Potentials. J. Comput. Chem., 17, 367, (1996).
Analysis of Hydroxylamine Glycosidic linkages: Structural Consequences of the NO bond in Calicheamicin. J. Am. Chem. Soc., 116, 3197, (1994).
Finding the Best Fit: A Novel Approach to Superimposing Molecules. Chemical Design Automation News, 8, 32, (1993).
Discovery of a New Class of Herbicides: Sulfonyl Carboxamides. ACS Symp. Ser., 504, Synthesis and Chemistry of Agrochemicals III, 75, (1992).
The Structure and Conformation of Hydroxylamine and Its Methylated Derivatives. J. Chem. Soc., Chem. Comm., 824, (1992).
Conformational Analysis of the N-O bond in the Calicheamicin Oligosaccharide. J. Am. Chem. Soc., 113, 4716, (1991).
Helixanes. The First Primary Helical Molecules: Polyoxapolyspiroalkanones. J. Am. Chem. Soc., 102, 2134, (1980)
An Unusual New Allene Cyclization Reaction: Synthesis of Dihydrofuran-3(2H)-ones. J. Am. Chem. Soc., 100, 7746, (1978).